In TCM : Sophora Flavescens Root : Ku Shen Jian Meridians associated : Heart, Urinary Bladder, Liver, Small Intestine and Large Intestine. However, the exact mechanisms of action of Ku Shen must be investigated in depth. My plant crushes seem to fall into a few distinct groups. ‘Regent’ is a popular cultivar that is distinguished from species plants by its faster growth rate, fuller oval-rounded crown, glossier deep green foliage, earlier age for first flowering and better disease resistance. Rutin is a bioflavonoid, or plant pigment, that is found in certain vegetables and fruits. Special Features and Information. Schisandra benefits include boosting mental performance, improving endurance, protecting vision, preventing premature aging, and reducing overall inflammation and stress. This formula is mainly indicated in downward flow of Damp-Heat. Sophora flavescens, the shrubby sophora, is a species of plant in the genus Sophora of the family Fabaceae. Johnston, in, Yang, Baburin, Plitzko, Hering, & Hamburger, 2011, Kavvadias, Monschein, Sand, Riederer, & Schreier, 2003; Kavvadias et al., 2004, Abdelhalim, Chebib, Aburjai, Johnston, & Hanrahan, 2004, Goutman, Waxemberg, Donate-Oliver, Pomata, & Calvo, 2003, Gavande, Karim, Johnston, Hanrahan, & Chebib, 2011, Wanzhu Hou CMD LAc DiplAC DiplCH (NCCAOM), ... Hanjie Wang MD, in, Treating Autoimmune Disease with Chinese Medicine, Renal Sodium-Glucose Transporter-2 Inhibitors as Antidiabetic Agents, Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome (Second Edition), Anika Niambi Al-Shura BSc., MSOM, Ph.D, in, Integrative Cardiovascular Chinese Medicine, The Treatment of Pain with Chinese Herbs and Acupuncture (Second Edition). After withdrawal and symptomatic treatment, there was full recovery in eight cases, and the rest improved markedly. Salvia continues to be a rich source of GABAA modulators (Kavvadias, Monschein, Sand, Riederer, & Schreier, 2003; Kavvadias et al., 2004). U.S. Plant Patent PP2,338 was issued in 1964. The species is hermaphrodite (has both male and female organs). (B) Chemical structure of fenugreek C-glycosides and clinically used SGLT2 inhibitors used for docking studies. This plant often grows on hillsides, grass slopes, or shrubs below 1,500 meters above sea level. A herbal record lists the following adverse effects of Ku shen: salivation, abnormal gait, dyspnea, tachycardia [85]. Inhibiting the central nervous system and having analgesic and anticonvulsant effects. LR-2 and LR-5, the Spring point and the Connecting point of the Liver channel respectively, eliminates Damp-Heat in the channel and relieve the pain, SP-9, the Sea point of the Spleen channel, eliminates Damp-Heat and activates the Spleen, KI-2 and KI-10, the Spring point and the Sea point of the Kidney channel respectively, promote the urination and eliminate Damp-Heat, BL-18, the Back Transporting point of the Liver, reduces the Heat in the Liver channel. It has a certain therapeutic effect on the pathological changes of heart, liver, stomach, large intestine and bladder meridians. Sophora davidii is a spiny, multi-stemmed, deciduous shrub that is native to southwestern China. General Information Māmane (Sophora chrysophylla) is a member of the Pea or Legume family (Fabaceae).There are about 50 species in the genus Sophora, with māmane as the sole representative in the Hawaiian Islands.. It is a commonly used ethnic medicine in Northwest China, which first appeared in in 1,970 AD. Ku Shen is the root of deuto shrub Sophora flavescens Ait. Benefits of Sophora Root Extract : 1. This tree is also called the “honey tree” due to its melliferous flowers . It takes a pretty cool plant to overcome a silly name like Sophora prostrata 'Little Baby’ but I think this one manages. Long Dan Cao Radix Gentianae 5g, Huang Lian Rhizoma Coptidis 5g and She Chuang Zi Fructus Cnidii 10g, etc, could be added to relieve the pain. HPLC-based activity profiling of extracts the traditional Chinese herbal drug Kushen (Sophora flavescens root) led to the identification of the 8-lavandulyl flavonoids, kushenol I, sophoraflavanone G, and (−)-kurarinone, and the related chalcone kuraridine as GABAA receptor modulators (Yang, Baburin, Plitzko, Hering, & Hamburger, 2011). Native Introduced Native and Introduced. A range of natural flavonoids, including quercetin (Fig. It can be found in Russia, Japan, India, North Korea, and China. 4). If there is a painful perineum, add CV-1 and KI-6 to clear Damp-Heat and relieve the pain in the perineum, If there are swollen genitals, add SP-6 to eliminate Damp-Heat and reduce the swelling, If the testicles are painful, add ST-29 and ST-30 to regulate the Qi, remove its stagnation and relieve the pain, If there is a painful vagina with leucorrhoea, add ST-30 and HT-8 to eliminate Damp-Heat and relieve the pain, If there is painful urination, add KI-4 to clear Damp-Heat, promote the urination and relieve the pain. The study found that the injection of Ku Shen can antagonize arrhythmia induced by aconitine. RHS Plant Finder 2020. In spring and autumn each year, people gather the roots of Sophora Flavescens, remove their fibrous roots and root tips, wash them with water, cut them into pieces, dry them in the sun, and make them into Chinese herbs. Salvia triloba, traditionally known as Greek sage on bioassay-guided fractionation yielded a variety of flavonoids and terpenoids as modulators (Abdelhalim, Chebib, Aburjai, Johnston, & Hanrahan, 2004) (Fig. Immune-stimulative activity that changes the immune response of HBV-transgenic mice from a Th2 (IL-4 and IL-10) to a Th1 (IFN-γ and IL-2) response has been also reported (Dong et al., 2002; Yang et al., 2002). Inhibiting the central nervous system and having analgesic and anticonvulsant effects. If there is a painful perineum, add Yan Hu Suo Rhizoma Corydalis 10g and Yu Jin Radix Curcumae 10g to regulate the Qi and Blood circulation and relieve the pain. These chemicals are thought to help with symptoms of menopause. Anti-bacteria and anti-arrhythmia. (A) Fenugreek C-glycosides bind to SGLT2 receptors in silico. The State Food and Drug Administration of China (SFDA) has received several reports of adverse reactions to Zhi xue capsule in recent years [7A, 8S]. Its seeds can be made into pesticides, and its bark can be made into sacks. In The Treatment of Pain with Chinese Herbs and Acupuncture (Second Edition), 2011. It can measure up to 20 or 25 m in height. It can fix Nitrogen. Inhibiting the heart, slowing heart rate, and weakening myocardial contractility. The dosage of Ku Shen should be controlled at 3-10g. Rutin is a substance with many health effects, especially for the circulatory system, including: Heart Healthy: Studies show that rutin benefits heart health by lowering cholesterol, promoting healthy circulation, and... Antioxidant: Rutin functions as … Sophora … The beneficial compounds contained within Sophora japonica may make it one of the best herbal supplements for hemorrhoids. Sophora japonica reduces cerebral infarction partly as a result of … Glabridin (Fig 5), another sedative-hypnotic flavonoid in extracts of liquorice, is a flumazenil-insensitive positive modulator of GABAA receptors in dorsal raphe neurons (Jin et al., 2013). It is in leaf all year, in flower from July to August, and the seeds ripen in September. Over 81,000 plants and where to buy them Sophora flavescens or Ku Shen, which in Chinese means “bitter root,” is an herb used in Traditional medicine to treat a wide variety of symptoms, with purported effects on the liver, intestinal tract, and skin. Click below on a thumbnail map or name for species profiles. According to , the medicinal property of Ku Shen is relatively cold, with a bitter taste. In multiple pain animal models, sophocarpine and oxysophocarpine have shown effective antiinflammatory effect by inhibiting the expression of PG E2 and cytokines (Gao et al., 2009; Yang et al., 2015). 1999), where it is often an important component of island vegetation: S. tetraptera (Kowhai) blossom is the national flower of New Zealand, while S. toromiro (Philippi) Skottsb. It is traditionally used to alleviate heat and toxin, and is said to disperse swellings. It is an evergreen. There are more than 100 kinds of traditional Chinese medicine prescriptions containing Ku Shen, such as Ku Shen Tang, Xiao Feng San, Hua Zhi Pian, and Danggui Kushen Wan. An herbal medicine, kushen, is obtained from the roots of Sophora japonica (Sophora flavescens) and is used as an anti-inflammatory and bitter-tasting stomachic. A small number of people taking it may cause stomach pain, heartburn, nausea, vomiting, constipation, or loss of appetite. Lab and animal studies have shown that some compounds can kill cancer cells and help fight certain viruses. It is indicated in copulation pain due to formation of Damp-Heat resulting from weakness of the Spleen. Oxymatrine has a similar effect to matrine, which occurs by affecting the calcium channel, GABA release (Lu, Yang, Deng, Wu, & Liu, 2015), and regulation of NR2B-containing NMDA receptor-ERK/CREB signaling (Liu et al., 2012; Wang, Cao, et al., 2013; Wang, Li, Dun, Xu, Hao, et al., 2013; Wang, Li, Dun, Xu, Jin, et al., 2013) in neuropathic pain models. Oxymatrine is known to help reduce the swelling associated with unhealthy blood vessels. Ku shen is a Chinese herbal remedy made from the root of S. falvescens. How much sophora flower should I take? It should not be taken with a drug containing Li Lu (Veratrum Nigrum). Sophora root health benefits come from its several different compounds that have been used for centuries and have been tested in modern pharmacology. At least one species, Sophora flavescens, is herbaceous instead of woody. Many natural flavonoids have been identified as influencing ionotropic GABA receptors through bioassay-guided fractionation of plant extracts (Fig. of the Leguminosae family. 5) was the most active of the negative modulators (Gavande, Karim, Johnston, Hanrahan, & Chebib, 2011). In Japan, berberine hydrochloride is available commercially. Recent evidence has pointed to the pain-relieving effect of some compounds from Ku Shen in several animal models (Fig. The actions of both compounds were flumazenil-insensitive. Matrine has been shown to alleviate pain induced by anticancer drugs, and produce an antinociceptive effect on vincristine-induced painful neuropathy mouse models (Dun et al., 2014) as well as an antinociceptive effect on neuropathic pain induced by chronic constriction injury (Wang, Cao, et al., 2013; Wang, Li, Dun, Xu, Hao, et al., 2013; Wang, Li, Dun, Xu, Jin, et al., 2013). 4. For this patient we used only Chinese herbal medicine: Shui Niu Jiao Bubali Cornu, Sheng Di Huang Rehmanniae Radix and Xuan Shen Scrophulariae Radix to clear pathogenic Heat-Toxin in the Ying and Xuefen; Huang Qin Scutellariae Radix, Bai Xian Pi Dictamni cortex, Zhi Zi Gardeniae Fructus, Tu Fu Ling Smilacis glabrae Rhizoma and Ku Shen Sophorae flavescentis Radix to clear pathogenic Heat-Toxin in the Qifen; Chi Shao Paeoniae Radix rubra and Mu Dan Pi Moutan Cortex to clear Heat and remove Blood stasis; Jing Jie Schizonepetae Herba and Fang Feng Saposhnikoviae Radix to dispel Wind and stop itching; Bai Shao Paeoniae Radix alba to nourish the Blood; and Cang Zhu Atractylodis Rhizoma to prevent a formula with too many bitter tasting and cold herbs from impairing the physiological function of the Stomach and Spleen. A small dose of matrine can enhance immunity, but a large dose of matrine can suppress immunity. Wanzhu Hou CMD LAc DiplAC DiplCH (NCCAOM), ... Hanjie Wang MD, in Treating Autoimmune Disease with Chinese Medicine, 2011. The paper concluded that the results are promising and indicate the need for further evaluation in HCV cases (Azzam et al., 2007). Johnston, in Advances in Pharmacology, 2015. Up to September 2008, 35 cases of adverse reactions associated with Zhi xue capsule had been reported, of which 21 were associated with abnormal liver function, cholestatic hepatitis, and drug-induced liver damage. It is one of the oldest herbs used in TCM to clear heat and dry dampness, purge fire, remove toxicity, eliminate parasites, and induce diuresis. In larger doses, nervous system stimulation with muscle spasm and seizures can occur. Sophora species are widely used in traditional medicine, but we grow them just for their good looks. Lin, in Side Effects of Drugs Annual, 2011. It also contains flavonoids, lignans, triterpenoid saponins, phenolic acids, and phenylpropanoids. It with Liu Huang (Sulfur) and Ku Fan (Dried Alum) can treat scabies. Further studies have shown that quercetin antagonizes GABAC receptors through a redox-independent allosteric mechanism that is prevented by ascorbic acid (Calero et al., 2013). It may also inhibit the 5-Alpha Reductase enzyme and PDE5 potently, promoting hair growth and erectogenesis. It has a medicinal history of more than 2,000 years. Sophora flavescens is an evergreen Shrub growing to 1.5 m (5ft) by 1 m (3ft 3in) at a slow rate. Buckwheat, most citrus, figs, and both black and green tea also contain rutin. This formula can clear the Heat, eliminate Damp and relieve the pain during the copulation. Treat chronic hepatitis B and chronic hepatitis C. 2. This medicinal herb is cultivated and used across China. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. It is one of the oldest herbs used in TCM to clear heat and dry dampness, purge fire, remove toxicity, eliminate parasites, and induce diuresis. Guan-hua Du, ... Yong-xiang Zhang, in Advances in Pharmacology, 2016. Treat cardiac diseases and skin diseases. Sophora from Japan is a tree from the Fabaceae family native to the temperate and hot regions of Asia. Overview Information Phellodendron is a plant. The generic name is derived from sophera, an Arabic name for a pea-flowered tree.. The variation in activity of these isoflavonoids suggests that further studies of subtype selectivity are warranted. The Plants Database includes the following 12 species of Sophora . Anika Niambi Al-Shura BSc., MSOM, Ph.D, in Integrative Cardiovascular Chinese Medicine, 2014. … These include flavanoids kurainone, sophoraflavanone G, kushenol K, and kushenol N isolated from Sophora flavescens,31 gneyulins A and B, stilbene trimers, and noidesols A and B, dihydroflavonol-C-glycosides, from the bark of Gnetum gnemonoides,32 alstiphyllanines E–H, picraline, and ajmaline-type alkaloids from Alstonia macrophylla,33 and luteolin, apigenin, 6-C-pentosyl-8-C-hexosyl apigenin, and 6-C-hexosyl-8-C-pentosyl luteolin isolated from Cynodon dactylon.34. It was first described to have anti-HCV and anti-hepatitis B virus (HBV) effects in a cell culture model (Chen et al., 2001b) and an animal model (Chen et al., 2001a). K. Chan, ... Z.X. Gentiana Draining the Liver Decoction. And Qing luo yin, a Chinese herbal remedy for rheumatoid arthritis, is a combination of extracts of Dioscorea hypoglauca, Phellodendron amurense, Sinomenium acutum, and S. flavescens. The formula has the function of dispelling Wind and clearing Heat and Toxin. Some studies have indicated that matrine exerts antinociceptive effects via the opioid receptors (Kamei et al., 1997), while other reports have shown that it can increase cholinergic activation in the CNS rather than act on opioid receptors directly (Yin & Zhu, 2005). In Chinese medicine, Ku Shen is often used to clear heat and dry dampness, kill worms, promote urination, treat acute bacterial dysentery, mycotic enteritis, chronic ulcerative colitis, esophagitis, tonsillitis, cervicitis, pelvic inflammation, vaginitis, neurodermatitis, scald, gonorrhea, arrhythmia, insomnia, and asthma. 8). Change Yellow (Discharge) Decoction. Using an in silico receptor docking method, we were able to show that two of the six fenugreek C-glycosides, namely, orientin and vitexin, bound strongly to SGLT2 receptors and exhibited low receptor docking energies (CDock-E) comparable to clinically approved “gliflozins” (Fig. 4). Anand S. Nair, ... Sreejayan Nair, in Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome (Second Edition), 2018, As the prototypical SGLT inhibitor phlorizin was first identified from the bark of the root of the apple tree, it is not surprising that several plant-based molecules may possess SGLT2 inhibitory activity and therefore emerge as potential drugs or drug templates. Ku Shen mainly contains alkaloids such as matrine, oxymatrine, isomatrine, sophocarpine, isosopho- carpine, sophoramine, oxysophocarpine. 2-Ethyl-7-hydroxy-3′,4′-methylenedioxy-6-propyl-isoflavone (Fig. At present our information about this plant is limited to a list of the nurseries that supply it. It typically grows to 6-8' tall. This plant is listed in the RHS Plant Finder book. It is contraindicated for use in hemorrhagic colitis and bacteriogeneous diarrhea, since it might make the symptoms worse and prolong the duration of treatment. The information on this website is for reference only. 3. It typically grows to 6-8' tall. These herbs are either not addressed in this volume of integrative medicine or are found in the relevant herb categories where they concern certain symptoms of hypertension, oliguria, azotemia and hematuria. Sophora japonica, also known as Huai Mi or Huai Hua , is edible and often used as a Chinese herb to stop bleeding. There have been three reports of adverse reactions such as nausea, vomiting, dizziness, bradycardia, palpitation, ataxia, pallor, sweating, seizures, and dysphasia. Reducing method is used on these points. The species are native to southeast Europe, southern Asia, Australasia, various Pacific islands, western South America, the western United States, Florida and Puerto Rico. Akihiko Komuro, in Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation, 2017. Sophora japonica contains both anti-hemorrhagic and anti-hemostatic substances. It with She Chuang Zi (Fructus Cnidii) and, It with Shi Wei (Folium Pyrrosiae), Che Qian Zi (Semen Plantaginis), and. Photos of Sophorae Flavescentis Radix and its medicinal components as well as its main analgesic components. It is hardy to zone (UK) 6. If there is lower back pain, add BL-23 and BL-58 to strengthen the lower back and relieve the pain. Sophora subprostrata was first recorded in the Kaibao Bencao (973 A.D.). Apples are full of rutin. A series of synthetic isoflavones have also been shown to act as modulators at recombinant GABAA receptors. Inhibiting Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus haemolyticus, Streptococcus pneumoniae, Streptococcus agalactiae, Escherichia coli, Proteus, Aerobacter, Salmonella cholerae, Salmonella pullorum, Clostridium wilfordii type B, Bacillus subtilis, Pseudomonas aeruginosa, Pseudomonas alkalogenes, Pseudomonas putida, Mycobacterium tuberculosis, Helicobacter pylori. It with Yu Zhu (Rhizoma Polygonati Odorati), Zhi Gan Cao (Radix Glycyrrhizae Preparata), Wu Wei Zi (Fructus Schisandrae), Dan Shen (Red sage), and Shan Zha (Hawthorn Fruit) can treat viral myocarditis. Modern studies have confirmed the various pharmacological activities of Ku Shen such as its antitumor (Wang, You, et al., 2015; Xiao, Wang, Wang, & Shen, 2013), antiviral (Liu, Zhu, Shi, & Yang, 2003), and antiinflammatory (Ji, Cui, Liang, Guan, & Li, 2013) effects. These compounds also act on the CNS, for example, by increasing the expression of GABAAα1 receptors (Xu et al., 2013). It grows in cool, damp climates. Sophora root has shown to have anticancer and antiviral benefits, whereby it can kill off cancer cells and some viruses. Product ratings(★) are only available.To view detailed reviews, go to ‘ My Atomy Mall > My Reviews ’ My Reviews Your valuable feedback will be forwarded to our Customer Support Center.We will strive to provide you with the highest quality service. Increasing the number of white blood cells, relieving asthma, and eliminating phlegm. Anti-cancer and anti-allergic. 16.3A and B). Copyright © 2020 Elsevier B.V. or its licensors or contributors. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/S1054358916000028, URL: https://www.sciencedirect.com/science/article/pii/B978044453717100723X, URL: https://www.sciencedirect.com/science/article/pii/B9780128093986000147, URL: https://www.sciencedirect.com/science/article/pii/B9780080453828001088, URL: https://www.sciencedirect.com/science/article/pii/B9780444537416000489, URL: https://www.sciencedirect.com/science/article/pii/S1054358914000428, URL: https://www.sciencedirect.com/science/article/pii/B9780443069741000129, URL: https://www.sciencedirect.com/science/article/pii/B9780128120194000167, URL: https://www.sciencedirect.com/science/article/pii/B9780124200142000168, URL: https://www.sciencedirect.com/science/article/pii/B9780702031793000502, Pharmacological Mechanisms and the Modulation of Pain, Wang, You, et al., 2015; Xiao, Wang, Wang, & Shen, 2013, Wang, Cao, et al., 2013; Wang, Li, Dun, Xu, Hao, et al., 2013; Wang, Li, Dun, Xu, Jin, et al., 2013, Liu et al., 2012; Wang, Cao, et al., 2013; Wang, Li, Dun, Xu, Hao, et al., 2013; Wang, Li, Dun, Xu, Jin, et al., 2013, Meyler's Side Effects of Drugs (Sixteenth Edition), Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation, A worldwide yearly survey of new data in adverse drug reactions, Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A, Jane R. Hanrahan, ... Graham A.R. Long Dan Xie Gan Wan Gentiaria Draining the Liver Pill. Antifibrotic activity of oxymatrine in d-galactosamine-induced rat liver fibrosis has been predicted to be partly through inhibition of lipid peroxidation. What Is Ku Shen (Sophora Root or Radix Sophorae Flavescentis), What Is Qin Pi (Cortex Fraxini or Ash Bark), What Is Gan Sui (Radix Kansui or Kansui Root), What Is Pine Nut (Pinoli, Song Zi Ren, or Semen Pini Koraiensis), What Is Yu Li Ren (Semen Pruni or Bush Cherry Pit), What Is Huo Ma Ren (Semen Cannabis, Fructus Cannabis, or Hemp Seeds). It can be made into an oral decoction or be used to soak and wash the affected part. Long Dan Cao Radix Gentianae 5g, Huang Lian Rhizoma Coptidis 5g, She Chuang Zi Fructus Cnidii 10g, Chi Shao Yao Radix Paeoniae Rubrae 10g and Pu Gong Ying Herba Taraxaci 10g, etc., should be added to clear the Heat, eliminate Damp and relieve the pain. Figure 5. CV-2, the crossing point of the Directing Vessel and the Liver channel, and LR-12 regulate the circulation of Qi, eliminate Damp-Heat and relieve the pain. Pregnant women and children should not take it. It is particularly diverse around the Pacific Ocean (Hurr et al. Have anticancer and antiviral benefits, whereby it can be made into an oral decoction or be used to and. Be made into an oral decoction or be used to soak and wash affected! Herbal supplements for hemorrhoids, tachycardia [ 85 ] into a single Find a plant service over... Inflammation, 2017 properties and is said to disperse swellings Shen ) is a cosmopolitan genus of about species. At least one species, sophora produces seed pods containing beans/peas to fall into a few distinct.! 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